Detection and Treatment of Vulnerable Plaques and Vulnerable Patients
نویسندگان
چکیده
منابع مشابه
Detection and treatment of vulnerable plaques and vulnerable patients: novel approaches to prevention of coronary events.
There is growing interest in the possibility that identification and treatment of vulnerable plaques and vulnerable patients can enhance the progress made against coronary artery disease. Innovations in medical therapy—statins and other agents—and novel interventional cardiology techniques— eg, drug-eluting stents— have significantly decreased the morbidity and mortality caused by coronary athe...
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High-risk plaques that are vulnerable to rupture demonstrate distinct morphological characteristics. They are differentiated from the lesions responsible for stable coronary artery disease by their large necrotic cores, thin-inflamed fibrous caps, and positive remodeling. Adiponectin is an adipocytokine that is reduced in obesity and type 2 diabetes. Hypoadiponectinemia has been associated with...
متن کاملVulnerable plaques, inflammation and newer imaging modalities.
Currently, inflammation is considered to be the central player in the pathogenesis of atherosclerosis. It leads to the formation of multiple plaques in the arterial beds including coronary vasculature. Recent studies using the latest imaging techniques have shown that in patients with acute coronary syndromes (ACS) multiple plaques are ruptured and have thrombus formation on them. Various facto...
متن کاملMolecular imaging of inflammation for detection of vulnerable atheromatous plaques.
Inflammation plays a major pathogenic role in the development of atheromatous plaques and the progression of atherosclerosis. Disruption of the fibrous cap of atheromatous lesions has been shown to lead to acute cardiovascular events. Atheromatous plaque disruption is the mechanism most commonly associated with the occurrence of acute coronary syndrome, i.e unstable angina and acute myocardial ...
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Coronary artery disease is the result of atherosclerotic changes to the coronary arterial wall, comprising endothelial dysfunction, vascular inflammation and deposition of lipid-rich macrophage foam cells. Certain high-risk atherosclerotic plaques are vulnerable to disruption, leading to rupture, thrombosis and the clinical sequelae of acute coronary syndrome. Though recognised as the gold stan...
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ژورنال
عنوان ژورنال: Circulation
سال: 2006
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.105.540013